Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13859177 | 0.93 | BACE1 (0.37) | BACE1BACE2 | |
| SCHEMBL13859165 | 0.81 | BACE1 (0.50) | BACE1BACE2 | |
| SCHEMBL13859217 | 0.78 | BACE1 (0.36) | BACE1BACE2 | |
| SCHEMBL13859237 | 0.77 | BACE1 (0.55) | BACE1BACE2 | |
| SCHEMBL13859504 | 0.74 | BACE1 (0.41) | BACE1BACE2 | |
| SCHEMBL13859227 | 0.74 | BACE1 (0.36) | BACE1BACE2 | |
| SCHEMBL620904 | 0.73 | BACE2 (0.57) | BACE2 | |
| SCHEMBL13858956 | 0.72 | BACE1 (0.48) | BACE1BACE2 | |
| SCHEMBL1979443 | 0.70 | BACE1 (0.51) | BACE1BACE2 | |
| SCHEMBL1980420 | 0.70 | BACE1 (0.41) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709992-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012156284-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-22 | — | — | WO | disclosed |