Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.82 |
| ▸ | KIT | P10721 | 14/20 | 0.82 |
| ▸ | FLT3 | P36888 | 14/20 | 0.82 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.50 |
| ▸ | FLT1 | P17948 | 3/20 | 0.50 |
| ▸ | FLT4 | P35916 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 3/20 | 0.49 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | CDK8 | P49336 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL420378 | 0.90 | KDR (1.00) | KDRKITFLT3PDGFRAPDGFRB | |
| SCHEMBL421205 | 0.83 | KDR (1.00) | KDRKITFLT3PDGFRAPDGFRB | |
| SCHEMBL422725 | 0.82 | KDR (0.92) | KDRKITFLT3PDGFRAPDGFRB | |
| SCHEMBL420912 | 0.81 | KDR (0.84) | KDRKITFLT3PDGFRAPDGFRB | |
| SCHEMBL421024 | 0.81 | KDR (0.84) | KDRKITFLT3PDGFRAPDGFRB | |
| SCHEMBL422667 | 0.81 | KDR (0.84) | KDRKITFLT3PDGFRAPDGFRB | |
| SCHEMBL425283 | 0.81 | KDR (0.84) | KDRKITFLT3PDGFRAPDGFRB | |
| SCHEMBL420386 | 0.79 | KDR (0.80) | KDRKITFLT3PDGFRAPDGFRB | |
| SCHEMBL232934 | 0.79 | KDR (1.00) | KDRKITFLT3PDGFRAPDGFRB | |
| SCHEMBL421536 | 0.78 | KDR (0.78) | KDRKITFLT3PDGFRAPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4810427-B2 | — | — | 2011-11-09 | — | — | JP | claimed |
| EP-1638941-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-03-29 | — | — | EP | claimed |
| WO-2004113304-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-29 | — | — | WO | claimed |