Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 5/20 | 0.43 |
| ▸ | MERTK | Q12866 | 5/20 | 0.43 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.43 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.43 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13860938 | 0.99 | KDR (0.48) | KDRCYP1A2CYP2D6AXLMERTK | |
| SCHEMBL13861177 | 0.98 | KDR (0.46) | KDRCYP1A2CYP2D6AXLMERTK | |
| SCHEMBL4337471 | 0.95 | KDR (0.47) | KDRCYP1A2CYP2D6AXLMERTK | |
| SCHEMBL13861232 | 0.93 | KDR (0.49) | KDRAXLMERTKBRAFRAF1 | |
| SCHEMBL4321306 | 0.93 | AXL (0.51) | KDRAXLMERTKBRAFRAF1 | |
| SCHEMBL200063 | 0.91 | KDR (0.55) | KDRAXLMERTKBRAFRAF1 | |
| SCHEMBL4339583 | 0.91 | AXL (0.48) | KDRAXLMERTKBRAFRAF1 | |
| SCHEMBL13860910 | 0.90 | KDR (0.55) | KDRAXLMERTKBRAFRAF1 | |
| SCHEMBL13861363 | 0.89 | KDR (0.42) | KDRAXLMERTKBRAFRAF1 | |
| SCHEMBL13861621 | 0.87 | KDR (0.47) | KDRBRAFGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531532-B2 | Hepatocyte growth factor receptor inhibitors; Antitumor agents, anticarcinogenic agents, angiogenesis inhibitors; pyrimidine derivatives like Pyrrolidine-1-carboxylic acid [6-(2-fluoro-4-{3-[2-(4-fluorophenyl)acetyl]thioureido}phenoxy)pyrimidin-4-yl]amide | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-05-12 | — | — | US | disclosed |
| US-7531532-B2 | Hepatocyte growth factor receptor inhibitors; Antitumor agents, anticarcinogenic agents, angiogenesis inhibitors; pyrimidine derivatives like Pyrrolidine-1-carboxylic acid [6-(2-fluoro-4-{3-[2-(4-fluorophenyl)acetyl]thioureido}phenoxy)pyrimidin-4-yl]amide | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-05-12 | — | — | US | disclosed |