Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15397991 | 1.00 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3CG | |
| SCHEMBL11967475 | 1.00 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3CG | |
| SCHEMBL15397995 | 1.00 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3CG | |
| SCHEMBL13861018 | 1.00 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3CG | |
| SCHEMBL11967454 | 0.90 | PIK3CA (0.62) | PIK3CAPIK3CDPIK3CG | |
| SCHEMBL11967379 | 0.89 | PIK3CA (0.64) | PIK3CAPIK3CDPIK3CG | |
| SCHEMBL12829702 | 0.83 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CG | |
| SCHEMBL12689239 | 0.82 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CG | |
| SCHEMBL1485287 | 0.82 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CG | |
| SCHEMBL1485463 | 0.82 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483278-B1 | BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | HOFFMANN LA ROCHE (CH) | 2013-12-25 | — | — | EP | claimed |
| EP-2845592-A1 | Benzoxazepin PI3K inhibitor compounds and methods of use | F. Hoffmann-La Roche AG (CH) | 2015-03-11 | — | — | EP | disclosed |
| EP-2711368-A1 | Benzoxazepin PI3K inhibitor compounds and methods of use | F. Hoffmann-La Roche AG (CH) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012156379-A1 | PIK3/P110α INHIBITORS FOR PREVENTION OF RESTENOSIS BY APPLICATION AS AN IMPLANT COATING | Universität Zürich (CH) | 2012-11-22 | — | — | WO | disclosed |