Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1417197 | 0.95 | MAPK14 (0.55) | MAPK14MAPK11MCHR1MAPKAPK2LCK | |
| SCHEMBL1417140 | 0.95 | MAPK14 (0.56) | MAPK14MAPK11MAPKAPK2LCKKIT | |
| SCHEMBL12810467 | 0.91 | MAPK14 (0.56) | MAPK14MAPK11MAPKAPK2LCKKIT | |
| SCHEMBL1386072 | 0.90 | MAPK14 (0.55) | MAPK14MAPK11MAPKAPK2LCKKIT | |
| SCHEMBL1382545 | 0.88 | MAPK14 (0.56) | MAPK14MAPK11MAPKAPK2LCKKIT | |
| SCHEMBL1385368 | 0.88 | MAPK14 (0.57) | MAPK14MAPK11MAPKAPK2LCKKIT | |
| SCHEMBL1417204 | 0.86 | MAPK14 (0.61) | MAPK14MAPK11KITMAPK13MAPK12 | |
| SCHEMBL1417250 | 0.85 | MAPK14 (0.60) | MAPK14MAPK11MAPKAPK2KDRMAPK13 | |
| SCHEMBL1386544 | 0.84 | MAPK14 (0.57) | MAPK14MAPK11KDRMAPK13MAPK12 | |
| SCHEMBL1385115 | 0.84 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4838121-B2 | — | — | 2011-12-14 | — | — | JP | claimed |
| JP-2007521278-A | — | — | 2007-08-02 | — | — | JP | claimed |
| EP-1641764-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | Novartis AG (CH) | 2006-04-05 | — | — | EP | claimed |
| WO-2005009973-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2005-02-03 | — | — | WO | claimed |