Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.82 |
| ▸ | LCK | P06239 | 1/20 | 0.71 |
| ▸ | CSF1R | P07333 | 1/20 | 0.71 |
| ▸ | IGF1R | P08069 | 1/20 | 0.71 |
| ▸ | MET | P08581 | 1/20 | 0.71 |
| ▸ | KIT | P10721 | 1/20 | 0.71 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.71 |
| ▸ | SRC | P12931 | 1/20 | 0.71 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.71 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.71 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.71 |
| ▸ | TEK | Q02763 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362208 | 1.00 | KDR (0.82) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL4367282 | 0.90 | KDR (1.00) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL4367190 | 0.90 | KDR (1.00) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL4371822 | 0.90 | KDR (0.72) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL13861964 | 0.90 | KDR (0.72) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL4362982 | 0.89 | KDR (1.00) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL4364757 | 0.87 | KDR (0.75) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL4364745 | 0.85 | KDR (0.80) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL4363892 | 0.84 | KDR (1.00) | KDRLCKCSF1RIGF1RMET | |
| SCHEMBL4365263 | 0.83 | KDR (0.66) | KDRLCKCSF1RIGF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531553-B2 | Heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-05-12 | — | — | US | disclosed |
| US-7531553-B2 | Heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-05-12 | — | — | US | disclosed |