Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 19/20 | 0.51 |
| ▸ | TACR2 | P21452 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464448 | 0.88 | GNRHR (0.65) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL4465985 | 0.85 | GNRHR (0.63) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL13864558 | 0.82 | GNRHR (0.46) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL13867370 | 0.81 | GNRHR (0.45) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL13864531 | 0.80 | GNRHR (0.43) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL4468341 | 0.77 | PRKCI (0.47) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL4471830 | 0.76 | GNRHR (0.78) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL3279181 | 0.76 | GNRHR (0.75) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL13324654 | 0.75 | GNRHR (0.77) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL4463451 | 0.73 | GNRHR (0.75) | GNRHRTACR2HRH2OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538113-B2 | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-26 | — | — | US | disclosed |
| US-7538113-B2 | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-26 | — | — | US | disclosed |