Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.59 |
| ▸ | TTR | P02766 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | DHODH | Q02127 | 1/20 | 0.59 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13867865 | 0.92 | KDR (0.72) | KDRLMNAPOLBMEN1KMT2A | |
| SCHEMBL3891696 | 0.91 | KDR (0.66) | KDRLMNAPOLBMEN1KMT2A | |
| SCHEMBL3894313 | 0.88 | KDR (0.63) | KDRLMNAPOLBMEN1KMT2A | |
| SCHEMBL13867891 | 0.87 | DDR2 (0.57) | KDRLMNAPOLBMEN1KMT2A | |
| SCHEMBL3892583 | 0.86 | KDR (0.69) | KDRLMNAPOLBMEN1KMT2A | |
| SCHEMBL4553298 | 0.85 | KDR (0.59) | KDRLMNAPOLBMEN1KMT2A | |
| SCHEMBL13867819 | 0.85 | KDR (0.68) | KDRLMNAPOLBMEN1KMT2A | |
| SCHEMBL13867806 | 0.84 | KDR (0.67) | KDRLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL187444 | 0.84 | KDR (0.72) | KDRLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL13867815 | 0.84 | KDR (0.66) | KDRLMNAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514564-B2 | Substituted amine derivatives and methods of use | AMGEN INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514564-B2 | Substituted amine derivatives and methods of use | AMGEN INC. (US) | 2009-04-07 | — | — | US | disclosed |