Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13867868 | 0.83 | KDR (0.63) | KDRNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL3889476 | 0.83 | KDR (0.67) | KDRNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL13867851 | 0.81 | KDR (0.56) | KDRNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL3890618 | 0.81 | KDR (0.60) | KDRNPC1RAB9ASMN1; SMN2PDGFRB | |
| SCHEMBL3889313 | 0.81 | KDR (0.60) | KDRNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL3892724 | 0.81 | PDGFRB (0.46) | KDRPDGFRBPDGFRAEGFRERBB2 | |
| SCHEMBL3893118 | 0.80 | KDR (0.52) | KDRNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL7053803 | 0.80 | KDR (0.58) | KDRNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL13867826 | 0.80 | KDR (0.60) | KDRNPC1RAB9ASMN1; SMN2PDGFRB | |
| SCHEMBL3891446 | 0.79 | KDR (0.53) | KDRNPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514564-B2 | Substituted amine derivatives and methods of use | AMGEN INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514564-B2 | Substituted amine derivatives and methods of use | AMGEN INC. (US) | 2009-04-07 | — | — | US | disclosed |