Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.35 |
| ▸ | PPARD | Q03181 | 8/20 | 0.35 |
| ▸ | PPARG | P37231 | 7/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3922058 | 0.88 | PPARA (0.47) | PPARAPPARDPPARGTP53MAPT | |
| SCHEMBL13868064 | 0.84 | PPARD (0.51) | PPARAPPARDPPARG | |
| SCHEMBL3931391 | 0.73 | PPARG (0.50) | PPARAPPARDPPARGTP53MAPT | |
| SCHEMBL3924017 | 0.73 | PPARD (0.68) | PPARAPPARDPPARG | |
| SCHEMBL3921059 | 0.73 | PPARD (0.45) | PPARAPPARDPPARGMTNR1AMTNR1B | |
| SCHEMBL13647654 | 0.72 | PPARD (0.44) | PPARAPPARDPPARGMTNR1AMTNR1B | |
| SCHEMBL3927910 | 0.72 | PPARD (0.51) | PPARAPPARDPPARGTP53MAPT | |
| SCHEMBL3928990 | 0.71 | PPARD (0.58) | PPARAPPARDPPARGPTPN1 | |
| SCHEMBL3918024 | 0.71 | PPARD (0.70) | PPARAPPARDPPARG | |
| SCHEMBL3919871 | 0.71 | PPARD (0.58) | PPARAPPARDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528160-B2 | Fused heterocyclic derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2009-05-05 | — | — | US | disclosed |