Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3902845 | 1.00 | MAPT (0.33) | MAPTHCRTR2GAAL3MBTL1MEN1 | |
| SCHEMBL3908174 | 0.90 | HCRTR2 (0.33) | MAPTHCRTR2GAAL3MBTL1HCRTR1 | |
| SCHEMBL13868456 | 0.90 | HCRTR2 (0.33) | MAPTHCRTR2GAAL3MBTL1HCRTR1 | |
| SCHEMBL13868458 | 0.88 | MAPT (0.32) | MAPTHCRTR2HCRTR1 | |
| SCHEMBL3905546 | 0.88 | MAPT (0.32) | MAPTHCRTR2HCRTR1 | |
| SCHEMBL3906547 | 0.85 | — | — | |
| SCHEMBL3905847 | 0.85 | SMN1; SMN2 (0.33) | MAPTL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13868453 | 0.85 | — | — | |
| SCHEMBL13868386 | 0.77 | MEN1 (0.37) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL3903176 | 0.70 | GRM2 (0.42) | MEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517532-B2 | Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-7517532-B2 | Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-04-14 | — | — | US | disclosed |