Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 19/20 | 0.67 |
| ▸ | LCK | P06239 | 6/20 | 0.67 |
| ▸ | TXK | P42681 | 6/20 | 0.67 |
| ▸ | SYK | P43405 | 6/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1623080 | 0.88 | ITK (0.64) | ITKLCKTXKSYKCHEK1 | |
| SCHEMBL1622620 | 0.87 | ITK (0.65) | ITKLCKTXKSYK | |
| SCHEMBL1620633 | 0.87 | ITK (0.65) | ITKLCKTXKSYK | |
| SCHEMBL1622893 | 0.85 | ITK (0.72) | ITKLCKTXKSYKCHEK1 | |
| SCHEMBL1621994 | 0.85 | ITK (0.72) | ITKLCKTXKSYKCHEK1 | |
| SCHEMBL1622709 | 0.85 | ITK (0.72) | ITKLCKTXKSYKCHEK1 | |
| SCHEMBL1622189 | 0.82 | LCK (0.56) | ITKLCKTXKSYKCHEK1 | |
| SCHEMBL1622213 | 0.80 | ITK (1.00) | ITKLCKTXKSYKCHEK1 | |
| SCHEMBL1622311 | 0.79 | ITK (0.62) | ITKLCKTXKSYKCHEK1 | |
| SCHEMBL13354245 | 0.79 | ITK (0.62) | ITKLCKTXKSYKCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7518000-B2 | Thienopyrazoles | AVENTIS PHARMACEUTICALS, INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-7518000-B2 | Thienopyrazoles | AVENTIS PHARMACEUTICALS, INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20070254937-A1 | Thienopyrazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2007-11-01 | — | — | US | disclosed |
| US-20070254937-A1 | Thienopyrazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254937-A1 | Thienopyrazoles | ITK, IL2, JAK2 | ITK 1/4885LCK 59/4885TXK 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.