Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.60 |
| ▸ | HRH1 | P35367 | 13/20 | 0.45 |
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | FNTA | P49354 | 2/20 | 0.37 |
| ▸ | FNTB | P49356 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13870568 | 0.91 | KCNH2 (0.49) | KCNH2HRH1HTR2AFNTAFNTB | |
| SCHEMBL13870552 | 0.90 | KCNH2 (0.66) | KCNH2HRH1HTR2AHTR2C | |
| SCHEMBL13870479 | 0.86 | KCNH2 (0.80) | KCNH2HRH1HTR2AHTR2CFNTA | |
| SCHEMBL13964319 | 0.83 | KCNH2 (0.77) | KCNH2HRH1HTR2AHTR2C | |
| SCHEMBL13870534 | 0.82 | KCNH2 (0.68) | KCNH2HRH1HTR2AHTR2C | |
| SCHEMBL13939616 | 0.82 | KCNH2 (0.70) | KCNH2HRH1HTR2AHTR2C | |
| SCHEMBL13870560 | 0.80 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL13870600 | 0.80 | KCNH2 (0.61) | KCNH2HRH1HTR2AHTR2C | |
| SCHEMBL13939743 | 0.79 | KCNH2 (0.66) | KCNH2HRH1HTR2AHTR2CFNTA | |
| SCHEMBL13939795 | 0.79 | KCNH2 (0.61) | KCNH2HRH1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524864-B2 | Methods of treating sleep disorders | HYPNION, INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-7524864-B2 | Methods of treating sleep disorders | HYPNION, INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-7482460-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7482460-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7411069-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-7411069-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-7355042-B2 | Treatment of CNS disorders using CNS target modulators | HYPNION, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-7355042-B2 | Treatment of CNS disorders using CNS target modulators | HYPNION, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-7326721-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326721-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |