SCHEMBL1387134

SCHEMBL1387134

O=C1CN(Cc2cccc(-c3ccc(Cl)s3)n2)CCN1Cc1cc2cnccc2[nH]1

nearest known ligand 0.63

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
F10 P00742 18/20 0.63
F2 P00734 2/20 0.50
PRMT5 O14744 1/20 0.36
WDR77 Q9BQA1 1/20 0.36
NAMPT P43490 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1384301 0.87 F10 (0.66) F10F2PRMT5WDR77
SCHEMBL1387140 0.87 F10 (0.63) F10F2PRMT5WDR77
SCHEMBL4062216 0.87 F10 (0.63) F10F2
SCHEMBL1653779 0.86 F10 (0.69) F10F2PRMT5WDR77
SCHEMBL1384672 0.86 F10 (0.62) F10F2PRMT5WDR77NAMPT
SCHEMBL1385205 0.84 F10 (0.62) F10F2PRMT5WDR77
SCHEMBL1386737 0.82 F10 (0.52) F10F2PRMT5WDR77
Trifluoroacetic Acid SCHEMBL1385585 0.81 F10 (0.57) F10F2
SCHEMBL27572555 0.81 F10 (0.45) F10F2PRMT5WDR77NAMPT
Trifluoroacetic Acid SCHEMBL1385035 0.81 F10 (0.58) F10F2PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4829449-B2 2011-12-07 JP claimed
JP-2003508353-A 2003-03-04 JP claimed
EP-1208097-A2 SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS Aventis Pharmaceuticals Inc. (US) 2002-05-29 EP claimed
WO-2001007436-A2 SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS AVENTIS PHARMACEUTICALS INC. (US) 2001-02-01 WO claimed