Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.78 |
| ▸ | CCR4 | P51679 | 13/20 | 0.64 |
| ▸ | CCR5 | P51681 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387415 | 0.88 | EDNRA (1.00) | EDNRACCR4CCR5 | |
| SCHEMBL7948489 | 0.87 | EDNRA (0.85) | EDNRACCR4CCR5 | |
| SCHEMBL1387374 | 0.81 | EDNRA (0.85) | EDNRACCR4CCR5 | |
| SCHEMBL1731921 | 0.78 | CCR4 (1.00) | EDNRACCR4CCR5 | |
| SCHEMBL6038631 | 0.78 | CCR4 (0.58) | EDNRACCR4 | |
| SCHEMBL1387150 | 0.78 | EDNRA (0.77) | EDNRACCR4 | |
| SCHEMBL1731970 | 0.77 | CCR4 (0.74) | EDNRACCR4CCR5 | |
| SCHEMBL6039032 | 0.76 | CCR4 (0.51) | EDNRACCR4 | |
| SCHEMBL1387397 | 0.76 | EDNRA (0.67) | EDNRACCR4 | |
| SCHEMBL1387409 | 0.76 | EDNRA (1.00) | EDNRACCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H09510987-A | — | — | 1997-11-04 | — | — | JP | claimed |
| EP-0752986-A1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1997-01-15 | — | — | EP | claimed |
| WO-1995026957-A1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1995-10-12 | — | — | WO | claimed |