Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 14/20 | 0.65 |
| ▸ | HASPIN | Q8TF76 | 6/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12070347 | 0.90 | DYRK1A (0.80) | DYRK1AHASPINACHEMAOAHTR2A | |
| SCHEMBL12070348 | 0.79 | DYRK1A (0.75) | DYRK1AHASPINACHEMAOAHTR2A | |
| SCHEMBL12070349 | 0.79 | DYRK1A (1.00) | DYRK1AHASPINACHEMAOAHTR2A | |
| SCHEMBL17502366 | 0.78 | DYRK1A (0.78) | DYRK1AHASPINHTR2AHTR2C | |
| SCHEMBL27917524 | 0.78 | DYRK1A (0.77) | DYRK1AHASPINACHEMAOAHTR2A | |
| SCHEMBL2215202 | 0.77 | DYRK1A (0.81) | DYRK1AHASPINACHEMAOAHTR2A | |
| SCHEMBL17102950 | 0.77 | DYRK1A (0.77) | DYRK1AHASPINHTR2AHTR2C | |
| SCHEMBL17502379 | 0.77 | DYRK1A (0.80) | DYRK1AHASPINHTR2AHTR2C | |
| SCHEMBL17102959 | 0.77 | DYRK1A (0.84) | DYRK1AHASPINMAOAHTR2AHTR2C | |
| SCHEMBL17517497 | 0.75 | DYRK1A (0.72) | DYRK1AHASPINHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050747-A1 | Dimers of harmol or of its derivatives and uses thereof | BioAlliance Pharma (FR) | 2009-04-22 | — | — | EP | disclosed |
| WO-2009047298-A2 | DIMERS OF HARMOL OR OF ITS DERIVATIVES AND USES THEREOF | BIOALLIANCE PHARMA (FR) | 2009-04-16 | — | — | WO | disclosed |