Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RPS27 | P42677 | 1/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13876485 | 0.87 | EPHX2 (0.64) | EPHX2NR1H4CA1CA2OPRM1 | |
| SCHEMBL13876475 | 0.85 | EPHX2 (0.68) | EPHX2NR1H4CA1CA2OPRM1 | |
| SCHEMBL13876333 | 0.82 | EPHX2 (0.58) | EPHX2MAPK8MAPK9MAPK10NR1H4 | |
| SCHEMBL13876489 | 0.80 | EPHX2 (0.64) | EPHX2CYP3A4MAPK8MAPK9MAPK10 | |
| SCHEMBL14456994 | 0.79 | EPHX2 (0.66) | EPHX2NR1H4CA1CA2OPRM1 | |
| SCHEMBL13876720 | 0.77 | EPHX2 (0.62) | EPHX2MAPK14CYP3A4 | |
| SCHEMBL13876484 | 0.76 | EPHX2 (0.69) | EPHX2NR1H4OPRM1OPRD1OPRK1 | |
| SCHEMBL4189504 | 0.76 | EPHX2 (0.82) | EPHX2NR1H4CA1CA2 | |
| SCHEMBL13876481 | 0.76 | EPHX2 (0.65) | EPHX2MAPK14NR1H4 | |
| SCHEMBL13876375 | 0.75 | GRM5 (0.53) | EPHX2MAPK14CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099184-A1 | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-16 | — | — | US | disclosed |
| US-20090099184-A1 | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-16 | — | — | US | disclosed |
| WO-2007098352-A2 | SUBSTITUTED PYRIDINEAMIDE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099184-A1 | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors | EPHX1, EPHX2, NCEH1 | EPHX2 2/4885MAPK14 2991/4885CYP3A4 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.