SCHEMBL1387734

SCHEMBL1387734

CC(C)c1nc(-c2ccc(F)cc2)c(-c2ccncc2)[nH]1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 14/20 0.67
MAPK13 O15264 13/20 0.67
MAPK12 P53778 13/20 0.67
MAPK11 Q15759 13/20 0.67
GCGR P47871 12/20 0.67
CSNK1D P48730 4/20 0.64
PRKD3 O94806 3/20 0.64
MAP4K4 O95819 3/20 0.64
FRK P42685 3/20 0.64
MAPK9 P45984 3/20 0.64
CSNK1A1 P48729 3/20 0.64
GSK3B P49841 3/20 0.64
CLK4 Q9HAZ1 3/20 0.64
PTK6 Q13882 2/20 0.64
PRKD2 Q9BZL6 2/20 0.64
BRAF P15056 2/20 0.62
KDM4E B2RXH2 2/20 0.60
ALOX5 P09917 6/20 0.58
PRKACA P17612 2/20 0.57
SLK Q9H2G2 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9646788 1.00 MAPK14 (0.67) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL9648774 0.92 KDM4E (0.70) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL9648933 0.87 KDM4E (0.82) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL5767827 0.85 MAPK14 (0.60) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL4919226 0.84 MAPK14 (0.58) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL9646725 0.83 KDM4E (0.58) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL7210440 0.82 MAPK14 (0.52) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL8113784 0.82 MAPK14 (0.60) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL6601709 0.82 MAPK14 (0.60) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL9784269 0.82 KDM4E (0.56) MAPK14MAPK13MAPK12MAPK11GCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0708768-B1 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORP (US) 2003-04-09 EP claimed
JP-H09500137-A 1997-01-07 JP claimed
EP-0708768-A4 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORP (US) 1996-08-21 EP claimed
EP-0708768-A1 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORPORATION (US) 1996-05-01 EP claimed
WO-1995002591-A1 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORPORATION (US) 1995-01-26 WO claimed
EP-1539121-A4 METHODS OF PROMOTING OSTEOGENESIS SCIOS INC (US) 2008-08-13 EP disclosed
EP-1583535-A4 METHODS FOR TREATING DIABETES SCIOS INC (US) 2008-03-19 EP disclosed
EP-1583535-A2 METHODS FOR TREATING DIABETES SCIOS INC. (US) 2005-10-12 EP disclosed
EP-1539121-A2 METHODS OF PROMOTING OSTEOGENESIS SCIOS INC. (US) 2005-06-15 EP disclosed
WO-2005032551-A1 TREATMENT OF CARDIOVASCULAR DISEASE WITH INHIBITORS OF p38 KINASE SCIOS INC. (US) 2005-04-14 WO disclosed
WO-2005030091-A2 STENTS AND INTRA-LUMINAL PROSTHESES CONTAINING MAP KINASE INHIBITORS SCIOS INC. (US) 2005-04-07 WO disclosed
WO-2004053107-A2 METHODS FOR TREATING DIABETES SCIOS INC. (US) 2004-06-24 WO disclosed
EP-0889888-A4 NOVEL TREATMENT FOR CNS INJURIES SMITHKLINE BEECHAM CORP (US) 2003-01-08 EP disclosed
EP-1021173-A1 USE OF CSAID?TM COMPOUNDS FOR THE MANAGEMENT OF UTERINE CONTRACTIONS IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) 2000-07-26 EP disclosed
WO-1999018942-A1 USE OF CSAIDTM COMPOUNDS FOR THE MANAGEMENT OF UTERINE CONTRACTIONS IMPERIAL COLLEGE INNOVATIONS LTD. (GB) 1999-04-22 WO disclosed
EP-0889888-A1 NOVEL TREATMENT FOR CNS INJURIES SMITHKLINE BEECHAM CORPORATION (US) 1999-01-13 EP disclosed
WO-1997035856-A1 NOVEL TREATMENT FOR CNS INJURIES SMITHKLINE BEECHAM CORPORATION (US) 1997-10-02 WO disclosed
EP-0708768-A4 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORP (US) 1996-08-21 EP disclosed
EP-0708768-A1 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORPORATION (US) 1996-05-01 EP disclosed
WO-1995002591-A1 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORPORATION (US) 1995-01-26 WO disclosed