Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.61 |
| ▸ | RAF1 | P04049 | 8/20 | 0.61 |
| ▸ | ABL1 | P00519 | 3/20 | 0.57 |
| ▸ | BCR | P11274 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | HCK | P08631 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.49 |
| ▸ | SIK1 | P57059 | 1/20 | 0.49 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.49 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13878745 | 0.96 | ABL1 (0.61) | BRAFRAF1ABL1BCRHDAC1 | |
| SCHEMBL13878749 | 0.90 | LYN (0.53) | BRAFRAF1ABL1BCRHDAC1 | |
| SCHEMBL13878750 | 0.89 | ABL1 (0.56) | BRAFRAF1ABL1BCRHDAC1 | |
| SCHEMBL1704880 | 0.88 | ABL1 (0.64) | BRAFRAF1ABL1BCRHDAC1 | |
| SCHEMBL13878753 | 0.88 | CSF1R (0.56) | BRAFRAF1ABL1BCRHDAC1 | |
| SCHEMBL13878743 | 0.88 | LYN (0.51) | BRAFRAF1ABL1BCRHDAC1 | |
| SCHEMBL1704685 | 0.88 | RAF1 (0.54) | BRAFRAF1ABL1BCRHDAC1 | |
| SCHEMBL1704444 | 0.87 | LCK (0.61) | BRAFRAF1LCK | |
| SCHEMBL13878739 | 0.86 | BRAF (0.58) | BRAFRAF1CSF1RLCKMAPK14 | |
| SCHEMBL13878805 | 0.85 | LYN (0.55) | BRAFRAF1ABL1BCRHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105250-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-04-23 | — | — | US | disclosed |
| US-20090105250-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105250-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | ABL1, BCR, PDGFRB | BRAF 8/4885RAF1 10/4885ABL1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.