⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388186 | 0.93 | PDE2A (0.39) | — | |
| SCHEMBL1387514 | 0.91 | GSK3B (0.40) | — | |
| SCHEMBL1388060 | 0.91 | GSK3B (0.45) | — | |
| SCHEMBL1387852 | 0.89 | — | — | |
| SCHEMBL1387572 | 0.89 | — | — | |
| SCHEMBL1387614 | 0.88 | — | — | |
| SCHEMBL1387825 | 0.87 | — | — | |
| SCHEMBL1388069 | 0.87 | PDE2A (0.41) | — | |
| SCHEMBL1387876 | 0.86 | PDE2A (0.42) | — | |
| SCHEMBL1387400 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708774-B1 | IMIDAZO[1,2-a]PYRAZIN-4-ONE DERIVATIVES ANTAGONISTS OF AMPA AND NMDA RECEPTORS | RHONE POULENC RORER SA (FR) | 1999-03-17 | — | — | EP | claimed |
| JP-H09500873-A | — | — | 1997-01-28 | — | — | JP | claimed |
| EP-0708774-A1 | IMIDAZO [1,2-A]PYRAZINE-4-ONE, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1996-05-01 | — | — | EP | claimed |
| WO-1995002601-A1 | IMIDAZO[1,2-a]PYRAZINE-4-ONE, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1995-01-26 | — | — | WO | claimed |
| EP-0708774-B1 | IMIDAZO[1,2-a]PYRAZIN-4-ONE DERIVATIVES ANTAGONISTS OF AMPA AND NMDA RECEPTORS | RHONE POULENC RORER SA (FR) | 1999-03-17 | — | — | EP | disclosed |
| EP-0708774-A1 | IMIDAZO [1,2-A]PYRAZINE-4-ONE, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002601-A1 | IMIDAZO[1,2-a]PYRAZINE-4-ONE, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1995-01-26 | — | — | WO | disclosed |