Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.83 |
| ▸ | PDE4A | P27815 | 6/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.59 |
| ▸ | CTSK | P43235 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388000 | 1.00 | PDE4B (0.83) | PDE4BPDE4APDE4CPDE4DCTSK | |
| SCHEMBL1388001 | 1.00 | PDE4B (0.83) | PDE4BPDE4APDE4CPDE4DCTSK | |
| SCHEMBL1387900 | 0.91 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DCTSK | |
| SCHEMBL1387898 | 0.91 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DCTSK | |
| SCHEMBL1387896 | 0.91 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DCTSK | |
| SCHEMBL1388334 | 0.84 | PDE4B (0.82) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1388332 | 0.84 | PDE4B (0.82) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1388336 | 0.84 | PDE4B (0.82) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1388018 | 0.83 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1388015 | 0.83 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720600-B1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ICOS CORP (US) | 2000-07-12 | — | — | EP | claimed |
| JP-H09502979-A | — | — | 1997-03-25 | — | — | JP | claimed |
| EP-0720600-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1996-07-10 | — | — | EP | claimed |
| WO-1995008534-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1995-03-30 | — | — | WO | claimed |
| EP-0720600-B1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ICOS CORP (US) | 2000-07-12 | — | — | EP | disclosed |
| US-5665754-A | Substituted pyrrolidines | GLAXO WELLCOME INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0720600-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008534-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1995-03-30 | — | — | WO | disclosed |