Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 13/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.41 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13880019 | 0.92 | CASR (0.55) | CASRKRASSOS1 | |
| SCHEMBL13868192 | 0.90 | CASR (0.52) | CASRKRASSOS1 | |
| SCHEMBL3921336 | 0.88 | CASR (0.57) | CASR | |
| SCHEMBL3934377 | 0.87 | CASR (0.51) | CASRKRASSOS1 | |
| SCHEMBL3926731 | 0.86 | CASR (0.59) | CASRHTR7ADRA2CSLC6A2HTR2C | |
| SCHEMBL3924565 | 0.85 | CASR (0.52) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL13868163 | 0.85 | CASR (0.55) | CASRKRAS | |
| SCHEMBL3925076 | 0.84 | CASR (0.45) | CASRHTR7CYP2D6 | |
| SCHEMBL13879973 | 0.84 | CASR (0.47) | CASRKRASSOS1 | |
| SCHEMBL13868197 | 0.84 | CASR (0.53) | CASRKRASSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524873-B2 | Substituted N-phenylmethyl ethanamines; N-((6-(methyloxy)-4'-(trifluoromethyl)-1,1'-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; parathyroid hormone inhibitors; antisecretory agents; osteoporosis | AMGEN INC. (US) | 2009-04-28 | — | — | US | disclosed |