Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK2 | Q16620 | 4/20 | 0.83 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.83 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.52 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925304 | 0.91 | NTRK2 (0.79) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL1924640 | 0.91 | NTRK2 (1.00) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL12537616 | 0.90 | NTRK1 (0.68) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL1926089 | 0.86 | NTRK2 (0.72) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL13885220 | 0.86 | NTRK2 (0.74) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL1925284 | 0.86 | NTRK2 (0.74) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL12537229 | 0.85 | NTRK2 (0.71) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL1925784 | 0.85 | NTRK2 (0.78) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL1925132 | 0.85 | NTRK2 (1.00) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL12537234 | 0.84 | NTRK2 (0.69) | NTRK2NTRK1EGFRERBB2ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514435-B2 | Pyrrolotriazine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070149534-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2007-06-28 | — | — | US | disclosed |
| WO-2007061882-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149534-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | NTRK2, NTRK3, NTRK1 | NTRK2 1/4885NTRK1 3/4885EGFR 169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.