Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.80 |
| ▸ | KDR | P35968 | 7/20 | 0.80 |
| ▸ | RET | P07949 | 4/20 | 0.80 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.80 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.80 |
| ▸ | ABL1 | P00519 | 3/20 | 0.80 |
| ▸ | SRC | P12931 | 3/20 | 0.80 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.80 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.80 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.80 |
| ▸ | BRAF | P15056 | 3/20 | 0.80 |
| ▸ | PLK4 | O00444 | 2/20 | 0.80 |
| ▸ | AURKA | O14965 | 2/20 | 0.80 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.80 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.80 |
| ▸ | LCK | P06239 | 2/20 | 0.80 |
| ▸ | FYN | P06241 | 2/20 | 0.80 |
| ▸ | LYN | P07948 | 2/20 | 0.80 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.80 |
| ▸ | AXL | P30530 | 2/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17433342 | 0.91 | KDR (0.82) | RAF1KDRRETAURKBEPHX2 | |
| SCHEMBL5568327 | 0.90 | RAF1 (0.80) | RAF1KDRRETAURKBEPHX2 | |
| SCHEMBL19878475 | 0.90 | RAF1 (0.80) | RAF1KDRRETAURKBEPHX2 | |
| Sorafenib SCHEMBL8218 | 0.89 | RAF1 (1.00) | RAF1KDRRETAURKBEPHX2 | |
| SCHEMBL10203624 | 0.89 | RAF1 (0.79) | RAF1KDRRETAURKBEPHX2 | |
| Sorafenib SCHEMBL14739751 | 0.89 | RAF1 (1.00) | RAF1KDRRETAURKBEPHX2 | |
| Sorafenib SCHEMBL29349634 | 0.89 | RAF1 (1.00) | RAF1KDRRETAURKBEPHX2 | |
| SCHEMBL1532269 | 0.89 | RAF1 (0.79) | RAF1KDRRETAURKBEPHX2 | |
| SCHEMBL549001 | 0.89 | RAF1 (1.00) | RAF1KDRRETAURKBEPHX2 | |
| Sorafenib SCHEMBL1533976 | 0.88 | RAF1 (0.98) | RAF1KDRRETAURKBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196991-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2023-10-12 | — | — | WO | disclosed |
| WO-2009055343-A2 | FULLY HUMAN ANTI-VEGF ANTIBODIES AND METHODS OF USING | SCHERING CORPORATION (US) | 2009-04-30 | — | — | WO | disclosed |