Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.66 |
| ▸ | GSK3B | P49841 | 12/20 | 0.66 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885152 | 0.90 | CDK2 (0.67) | CDK2GSK3BMAPKAPK2CCNE1FLT3 | |
| SCHEMBL13309212 | 0.85 | CDK2 (0.58) | CDK2GSK3BMAPKAPK2CCNE1FLT3 | |
| SCHEMBL14427533 | 0.83 | CDK2 (0.65) | CDK2GSK3BMAPKAPK2CCNE1FLT3 | |
| SCHEMBL14427535 | 0.82 | CDK2 (0.78) | CDK2GSK3BMAPKAPK2CCNE1FLT3 | |
| SCHEMBL14427541 | 0.81 | CDK2 (0.83) | CDK2GSK3BMAPKAPK2CCNE1FLT3 | |
| SCHEMBL14427515 | 0.81 | CDK2 (0.82) | CDK2GSK3BMAPKAPK2CCNE1FLT3 | |
| SCHEMBL14427485 | 0.79 | CDK2 (1.00) | CDK2GSK3BMAPKAPK2CCNE1FLT3 | |
| SCHEMBL13998536 | 0.79 | GSK3B (0.54) | CDK2GSK3BMAPKAPK2CSNK2B | |
| SCHEMBL14427488 | 0.79 | CDK2 (1.00) | CDK2GSK3BMAPKAPK2CCNE1FLT3 | |
| SCHEMBL14427362 | 0.79 | CDK2 (1.00) | CDK2GSK3BMAPKAPK2CCNE1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514442-B2 | Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514442-B2 | Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |