Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 5/20 | 0.55 |
| ▸ | CDK2 | P24941 | 9/20 | 0.44 |
| ▸ | GSK3B | P49841 | 8/20 | 0.44 |
| ▸ | CDK9 | P50750 | 5/20 | 0.42 |
| ▸ | CDK7 | P50613 | 3/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CCNK | O75909 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | CCNH | P51946 | 2/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.42 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 4/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.40 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885686 | 0.98 | BCL6 (0.53) | BCL6CDK2GSK3BCDK9CDK7 | |
| SCHEMBL13885687 | 0.91 | CDK2 (0.52) | BCL6CDK2GSK3BCDK9CDK7 | |
| SCHEMBL13885155 | 0.91 | BCL6 (0.58) | BCL6CDK2GSK3BCDK9CDK7 | |
| SCHEMBL13885151 | 0.91 | BCL6 (0.58) | BCL6CDK2GSK3BCDK9CDK7 | |
| SCHEMBL13885164 | 0.88 | BCL6 (0.55) | BCL6CDK2GSK3BCDK9CDK7 | |
| SCHEMBL14528836 | 0.84 | GSK3B (0.50) | BCL6CDK2GSK3BCDK9CDK7 | |
| SCHEMBL13885173 | 0.82 | CDK2 (0.54) | BCL6CDK2GSK3BCDK9CDK7 | |
| SCHEMBL13998537 | 0.79 | BCL6 (0.63) | BCL6CDK2GSK3BCDK9CDK7 | |
| SCHEMBL13998529 | 0.79 | BCL6 (0.63) | BCL6CDK2GSK3BCDK9CDK7 | |
| SCHEMBL13885698 | 0.79 | CDK2 (0.52) | CDK2GSK3BCCNE1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514442-B2 | Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |