Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK1 | Q9BQI3 | 9/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040110 | 0.87 | EIF2AK1 (0.44) | EIF2AK1PDGFRBCHEK1 | |
| SCHEMBL4052068 | 0.85 | EIF2AK1 (0.58) | EIF2AK1PDGFRBCHEK1 | |
| SCHEMBL4041882 | 0.85 | EIF2AK1 (0.56) | EIF2AK1PDGFRBCHEK1 | |
| SCHEMBL4053015 | 0.84 | EIF2AK1 (0.46) | EIF2AK1PDGFRBCHEK1 | |
| SCHEMBL4040936 | 0.84 | EIF2AK1 (0.52) | EIF2AK1PDGFRBCHEK1 | |
| SCHEMBL4046433 | 0.80 | EIF2AK1 (0.42) | EIF2AK1PDGFRBCHEK1 | |
| SCHEMBL4044259 | 0.79 | EIF2AK1 (0.54) | EIF2AK1PDGFRBCHEK1 | |
| SCHEMBL4041028 | 0.78 | EIF2AK1 (0.67) | EIF2AK1PDGFRBCHEK1 | |
| SCHEMBL4044469 | 0.77 | EIF2AK1 (0.55) | EIF2AK1PDGFRBCHEK1 | |
| SCHEMBL4045489 | 0.76 | EIF2AK1 (0.68) | EIF2AK1PDGFRBCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | disclosed |