Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.50 |
| ▸ | MLYCD | O95822 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | CYP3A5 | P20815 | 3/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10044245 | 0.80 | CYP19A1 (0.49) | KCNA5CYP19A1CYP3A4CYP1A2CYP3A5 | |
| SCHEMBL27888098 | 0.79 | CYP19A1 (0.52) | KCNA5CYP19A1CYP3A4CYP1A2CYP3A5 | |
| SCHEMBL29583661 | 0.78 | CYP19A1 (0.53) | KCNA5CYP19A1CYP3A4CYP1A2CYP3A5 | |
| SCHEMBL851325 | 0.78 | CYP19A1 (0.53) | KCNA5CYP19A1CYP3A4CYP1A2CYP3A5 | |
| SCHEMBL29387897 | 0.78 | CYP19A1 (0.57) | KCNA5CYP19A1CYP3A4CYP1A2CYP3A5 | |
| SCHEMBL19627972 | 0.78 | CYP19A1 (0.57) | KCNA5CYP19A1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL13577 | 0.78 | CYP19A1 (0.57) | KCNA5CYP19A1CYP3A4CYP1A2CYP3A5 | |
| SCHEMBL7068828 | 0.78 | CYP19A1 (0.57) | KCNA5CYP19A1CYP3A4CYP1A2CYP3A5 | |
| SCHEMBL12184860 | 0.76 | KCNA5 (0.46) | KCNA5CYP19A1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL17963323 | 0.76 | CYP3A4 (0.46) | KCNA5CYP19A1CYP3A4CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524969-B2 | Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-04-28 | — | — | US | disclosed |
| US-7524969-B2 | Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-04-28 | — | — | US | disclosed |