Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515295 | 1.00 | CDK2 (0.32) | CDK2EZH2GPR84PTGS2 | |
| SCHEMBL7515294 | 1.00 | CDK2 (0.32) | CDK2EZH2GPR84PTGS2 | |
| SCHEMBL1389051 | 1.00 | CDK2 (0.32) | CDK2EZH2GPR84PTGS2 | |
| SCHEMBL7512816 | 1.00 | CDK2 (0.32) | CDK2EZH2GPR84PTGS2 | |
| SCHEMBL1388949 | 1.00 | CDK2 (0.32) | CDK2EZH2GPR84PTGS2 | |
| SCHEMBL7514668 | 1.00 | CDK2 (0.32) | CDK2EZH2GPR84PTGS2 | |
| SCHEMBL7514661 | 1.00 | CDK2 (0.32) | CDK2EZH2GPR84PTGS2 | |
| Hydrochloric Acid SCHEMBL7596062 | 0.99 | CDK2 (0.32) | CDK2EZH2GPR84 | |
| SCHEMBL7511556 | 0.94 | EZH2 (0.32) | EZH2GPR84 | |
| SCHEMBL1388976 | 0.94 | EZH2 (0.32) | EZH2GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686147-B1 | NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | PHARMACIA ITALIA SPA (IT) | 2002-09-25 | — | — | EP | claimed |
| EP-0866701-B1 | SYNERGISTIC IMMUNOSUPPRESSANT COMPOSITION CONTAINING A 2,2'-BI-1H-PYRROLE COMPOUND | PHARMACIA & UPJOHN SPA (IT) | 2002-01-16 | — | — | EP | claimed |
| EP-0825983-B1 | PROCESS FOR THE PREPARATION OF 2,2'-BIPYRROLYL-PYRROMETHENE (PRODIGIOSINS) DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2001-08-29 | — | — | EP | claimed |
| JP-H08507090-A | — | — | 1996-07-30 | — | — | JP | claimed |
| EP-0686147-A1 | NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-12-13 | — | — | EP | claimed |
| WO-1995017381-A1 | NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | PHARMACIA S.P.A. (IT) | 1995-06-29 | — | — | WO | claimed |
| EP-0686147-B1 | NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | PHARMACIA ITALIA SPA (IT) | 2002-09-25 | — | — | EP | disclosed |
| EP-1241162-A1 | 2,2'-bi-1H-pyrrole derivatives with immunosuppressant activity | Pharmacia Italia S.p.A. (IT) | 2002-09-18 | — | — | EP | disclosed |
| EP-0866701-B1 | SYNERGISTIC IMMUNOSUPPRESSANT COMPOSITION CONTAINING A 2,2'-BI-1H-PYRROLE COMPOUND | PHARMACIA & UPJOHN SPA (IT) | 2002-01-16 | — | — | EP | disclosed |
| US-6291509-B1 | Synergistic immunosuppressant composition containing a 2,2'-bi-1H-pyrrole compound | PHARMACIA & UPJOHN SPA (IT) | 2001-09-18 | — | — | US | disclosed |
| EP-0825983-B1 | PROCESS FOR THE PREPARATION OF 2,2'-BIPYRROLYL-PYRROMETHENE (PRODIGIOSINS) DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2001-08-29 | — | — | EP | disclosed |
| US-5847127-A | Process for the preparation of 2,2'-bipyrrolyl-pyrromethene (prodigiosins) derivatives | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-12-08 | — | — | US | disclosed |
| US-5691334-A | IMMUNOMODULATORS FOR SKIN GRAFTS, AUTOIMMUNE AND FOR ORGAN TRANSPLANTS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-11-25 | — | — | US | disclosed |
| EP-0686147-A1 | NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-12-13 | — | — | EP | disclosed |
| WO-1995017381-A1 | NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | PHARMACIA S.P.A. (IT) | 1995-06-29 | — | — | WO | disclosed |