SCHEMBL1389127

SCHEMBL1389127

N#CCc1nc(-c2ccc(F)cc2)c(-c2ccncc2)[nH]1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 16/20 0.62
MAPK13 O15264 13/20 0.62
MAPK12 P53778 13/20 0.62
MAPK11 Q15759 13/20 0.62
GCGR P47871 12/20 0.62
ALOX5 P09917 5/20 0.60
CSNK1D P48730 4/20 0.59
PRKD3 O94806 2/20 0.59
MAP4K4 O95819 2/20 0.59
FRK P42685 2/20 0.59
MAPK9 P45984 2/20 0.59
CSNK1A1 P48729 2/20 0.59
GSK3B P49841 2/20 0.59
PTK6 Q13882 2/20 0.59
CLK4 Q9HAZ1 2/20 0.59
PRKD2 Q9BZL6 1/20 0.59
BRAF P15056 2/20 0.54
CSNK1E P49674 3/20 0.54
KDM4E B2RXH2 1/20 0.53
CIT O14578 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8828356 0.82 MAPK13 (0.73) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL4553642 0.82 MAPK14 (0.66) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL19868921 0.81 MAPK14 (0.62) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL19869016 0.80 MAPK14 (0.70) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL19868919 0.78 BRAF (0.65) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL1387673 0.78 MAPK14 (0.62) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL1387676 0.78 MAPK14 (0.62) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL9007054 0.78 KDM4E (0.50) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL1387719 0.77 MAPK14 (0.62) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL1387728 0.77 MAPK14 (0.67) MAPK14MAPK13MAPK12MAPK11GCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-H09500137-A 1997-01-07 JP claimed
EP-0708768-A4 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORP (US) 1996-08-21 EP claimed
EP-0708768-A1 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORPORATION (US) 1996-05-01 EP claimed
WO-1995002591-A1 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORPORATION (US) 1995-01-26 WO claimed
EP-1539121-A4 METHODS OF PROMOTING OSTEOGENESIS SCIOS INC (US) 2008-08-13 EP disclosed
EP-1545535-A4 TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE SCIOS INC (US) 2008-06-04 EP disclosed
EP-1583535-A4 METHODS FOR TREATING DIABETES SCIOS INC (US) 2008-03-19 EP disclosed
EP-1583535-A2 METHODS FOR TREATING DIABETES SCIOS INC. (US) 2005-10-12 EP disclosed
EP-1545535-A2 TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE SCIOS INC. (US) 2005-06-29 EP disclosed
EP-1539121-A2 METHODS OF PROMOTING OSTEOGENESIS SCIOS INC. (US) 2005-06-15 EP disclosed
WO-2005032551-A1 TREATMENT OF CARDIOVASCULAR DISEASE WITH INHIBITORS OF p38 KINASE SCIOS INC. (US) 2005-04-14 WO disclosed
WO-2005030091-A2 STENTS AND INTRA-LUMINAL PROSTHESES CONTAINING MAP KINASE INHIBITORS SCIOS INC. (US) 2005-04-07 WO disclosed
WO-2004019873-A9 METHODS OF PROMOTING OSTEOGENESIS SCIOS INC (US) 2004-06-24 WO disclosed
WO-2004053107-A2 METHODS FOR TREATING DIABETES SCIOS INC. (US) 2004-06-24 WO disclosed
WO-2004024083-A2 METHODS OF BONE HEALING UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) 2004-03-25 WO disclosed
WO-2004021988-A2 TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE SCIOS INC. (US) 2004-03-18 WO disclosed
WO-2004019873-A2 METHODS OF PROMOTING OSTEOGENESIS SCIOS INC. (US) 2004-03-11 WO disclosed
EP-0708768-A4 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORP (US) 1996-08-21 EP disclosed
EP-0708768-A1 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORPORATION (US) 1996-05-01 EP disclosed
WO-1995002591-A1 TRI-SUBSTITUTED IMIDAZOLES HAVING MULTIPLE THERAPEUTIC PROPERTIES SMITHKLINE BEECHAM CORPORATION (US) 1995-01-26 WO disclosed