Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 19/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147142 | 1.00 | GCK (0.63) | GCKKCNH2NPC1HPGDRAB9A | |
| SCHEMBL1146875 | 0.92 | GCK (0.67) | GCKKCNH2 | |
| SCHEMBL13891595 | 0.92 | GCK (0.67) | GCKKCNH2 | |
| SCHEMBL1147144 | 0.89 | NPC1 (0.51) | GCKKCNH2NPC1HPGDRAB9A | |
| SCHEMBL1147195 | 0.88 | GCK (0.71) | GCKKCNH2NPC1HPGDRAB9A | |
| SCHEMBL13891577 | 0.88 | GCK (0.71) | GCKKCNH2NPC1HPGDRAB9A | |
| SCHEMBL13891583 | 0.85 | GCK (0.74) | GCKKCNH2 | |
| SCHEMBL12858465 | 0.85 | GCK (0.74) | GCKKCNH2 | |
| SCHEMBL2658987 | 0.84 | GCK (0.63) | GCKKCNH2 | |
| SCHEMBL13891674 | 0.82 | GCK (0.70) | GCKKCNH2NPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048137-A1 | Benzamide derivatives and their use as glucokinase activating agents. | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |