Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 20/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12858678 | 1.00 | GCK (0.79) | GCKKCNH2 | |
| SCHEMBL14007310 | 0.92 | GCK (0.78) | GCKKCNH2 | |
| SCHEMBL13891583 | 0.91 | GCK (0.74) | GCKKCNH2 | |
| SCHEMBL12858465 | 0.91 | GCK (0.74) | GCKKCNH2 | |
| SCHEMBL1147087 | 0.90 | GCK (0.75) | GCKKCNH2 | |
| SCHEMBL13891596 | 0.90 | GCK (0.75) | GCKKCNH2 | |
| SCHEMBL12858679 | 0.89 | GCK (0.74) | GCKKCNH2 | |
| SCHEMBL13891576 | 0.89 | GCK (0.74) | GCKKCNH2 | |
| SCHEMBL12021630 | 0.89 | GCK (0.77) | GCKKCNH2 | |
| SCHEMBL2657877 | 0.88 | GCK (0.77) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048137-A1 | Benzamide derivatives and their use as glucokinase activating agents. | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |