SCHEMBL13893755

CC(C)(C)OC(=O)N[C@@H](Cc1ccc(C(F)(F)F)cc1)CN(C(=O)OC(C)(C)C)c1nc(C(C)(C)O)c(-c2ccc3cnccc3c2)s1

nearest known ligand 0.40

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	AKT1	P31749	9/20	0.40

▸	CDK2	P24941	7/20	0.40

▸	SGK1	O00141	1/20	0.40

▸	ROCK2	O75116	1/20	0.33

▸	PTPRB	P23467	1/20	0.33

▸	TRPV1	Q8NER1	1/20	0.32

▸	CYP3A4	P08684	5/20	0.32

▸	PPARG	P37231	1/20	0.32

▸	PPARA	Q07869	1/20	0.32

▸	AAK1	Q2M2I8	2/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4294379	0.91	AKT1 (0.41)	AKT1CDK2SGK1ROCK2PTPRB
SCHEMBL4294376	0.90	AKT1 (0.40)	AKT1CDK2SGK1ROCK2PTPRB
SCHEMBL4294382	0.90	AKT1 (0.40)	AKT1CDK2SGK1ROCK2PTPRB
SCHEMBL4298351	0.90	AKT1 (0.38)	AKT1CDK2SGK1ROCK2PTPRB
SCHEMBL4298357	0.90	AKT1 (0.38)	AKT1CDK2SGK1ROCK2PTPRB
SCHEMBL4291758	0.90	AKT1 (0.40)	AKT1CDK2SGK1ROCK2PTPRB
SCHEMBL4291766	0.90	AKT1 (0.40)	AKT1CDK2SGK1ROCK2PTPRB
SCHEMBL4301332	0.90	AKT1 (0.40)	AKT1CDK2SGK1ROCK2PTPRB
SCHEMBL4301329	0.90	AKT1 (0.40)	AKT1CDK2SGK1ROCK2PTPRB
SCHEMBL4291762	0.90	AKT1 (0.40)	AKT1CDK2SGK1ROCK2PTPRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7514566-B2	Thiazole compounds and methods of use	AMGEN, INC. (US)	2009-04-07	—	—	US	disclosed