Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8737222 | 0.93 | BTK (0.58) | BTKKDM4ERAB9ACLK2TYK2 | |
| SCHEMBL106616 | 0.92 | BTK (0.66) | BTKCLK2 | |
| SCHEMBL3804473 | 0.82 | BTK (0.63) | BTKKDM4ERAB9ACLK2TYK2 | |
| SCHEMBL3660016 | 0.81 | BTK (0.62) | BTKKDM4ERAB9ACLK2TYK2 | |
| SCHEMBL710063 | 0.80 | BTK (0.75) | BTKKDM4ERAB9ACLK2 | |
| SCHEMBL16417074 | 0.79 | BTK (0.57) | BTKKDM4ERAB9ACLK2TYK2 | |
| SCHEMBL19594126 | 0.77 | BTK (0.85) | BTKCLK2 | |
| SCHEMBL104439 | 0.77 | BTK (0.77) | BTKCLK2 | |
| SCHEMBL2492566 | 0.77 | BTK (0.60) | BTKKDM4ERAB9ACLK2TYK2 | |
| SCHEMBL19593975 | 0.77 | BTK (0.69) | BTKKDM4ERAB9ACLK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |