Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 10/20 | 0.49 |
| ▸ | CDK2 | P24941 | 10/20 | 0.49 |
| ▸ | BTK | Q06187 | 6/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13894053 | 0.85 | BTK (0.45) | CCNE1CDK2BTK | |
| SCHEMBL13894044 | 0.83 | BTK (0.51) | BTK | |
| SCHEMBL13893944 | 0.82 | BTK (0.53) | BTK | |
| SCHEMBL13894043 | 0.82 | BTK (0.49) | BTK | |
| SCHEMBL13893941 | 0.81 | BTK (0.55) | BTK | |
| SCHEMBL103720 | 0.81 | BTK (0.47) | CCNE1CDK2BTK | |
| SCHEMBL13893894 | 0.78 | BTK (0.45) | BTKTP53MAPT | |
| SCHEMBL13893893 | 0.78 | BTK (0.48) | BTKTP53MAPT | |
| SCHEMBL13894015 | 0.77 | BTK (0.46) | BTKTP53MAPT | |
| SCHEMBL13893892 | 0.76 | BTK (0.52) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |