SCHEMBL13894070

SCHEMBL13894070

Cc1ccc(C(=O)Nc2cccc(-c3cc(Nc4ccc(C(=O)N5CCOCC5)cn4)c(=O)n(C)c3)c2C)cc1

nearest known ligand 0.88

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BTK Q06187 20/20 0.88
CLK2 P49760 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL102343 0.93 BTK (1.00) BTKCLK2
SCHEMBL1322849 0.92 BTK (0.82) BTKCLK2
SCHEMBL1321815 0.91 BTK (0.94) BTKCLK2
SCHEMBL12602983 0.88 BTK (0.75) BTKCLK2
SCHEMBL4078372 0.87 BTK (0.73) BTKCLK2
SCHEMBL13894025 0.86 BTK (0.67) BTKCLK2
SCHEMBL3866373 0.86 BTK (0.88) BTKCLK2
SCHEMBL1322755 0.86 BTK (0.86) BTKCLK2
SCHEMBL1323092 0.86 BTK (0.86) BTKCLK2
SCHEMBL1323347 0.86 BTK (0.74) BTKCLK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009053269-A1 NOVEL KINASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2009-04-30 WO disclosed