Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.34 |
| ▸ | RAMP1 | O60894 | 4/20 | 0.33 |
| ▸ | CALCRL | Q16602 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969014 | 0.91 | RAMP1 (0.37) | POLBADRB3ADRA2BADRA2CRAMP1 | |
| SCHEMBL13881545 | 0.91 | RAMP1 (0.37) | POLBADRB3ADRA2BADRA2CRAMP1 | |
| SCHEMBL8276998 | 0.91 | RAMP1 (0.37) | POLBADRB3ADRA2BADRA2CRAMP1 | |
| SCHEMBL3970706 | 0.83 | ADRB3 (0.50) | POLBALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL3974770 | 0.83 | ADRB3 (0.50) | POLBALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL3974766 | 0.83 | ADRB3 (0.50) | POLBALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL3965612 | 0.83 | ADRB3 (0.34) | POLBADRB3ADRA2BADRA2C | |
| SCHEMBL8278921 | 0.83 | ADRB3 (0.34) | POLBADRB3ADRA2BADRA2C | |
| SCHEMBL3967460 | 0.83 | ADRB3 (0.43) | POLBALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL3968301 | 0.83 | ADRB3 (0.48) | POLBALDH1A1LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680137-B1 | Macrocyclic carboxylic acid and acylsulfonamide compound as inhibitor of HCV replication | HOFFMANN LA ROCHE (CH) | 2012-11-21 | — | — | EP | disclosed |