Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.49 |
| ▸ | IGF1R | P08069 | 4/20 | 0.46 |
| ▸ | CDK1 | P06493 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 6/20 | 0.43 |
| ▸ | SRC | P12931 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | ITK | Q08881 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13648554 | 0.86 | SYK (0.60) | SYKCDK1CDK2CCNB1CCNE1 | |
| SCHEMBL13901453 | 0.86 | SYK (0.49) | SYKIGF1RCDK1CDK2ABL1 | |
| SCHEMBL13897817 | 0.84 | SYK (0.52) | SYKCDK1CDK2CCNB1CCNE1 | |
| SCHEMBL3867551 | 0.82 | CDK1 (0.45) | SYKIGF1RCDK1CDK2CCNB1 | |
| SCHEMBL13897528 | 0.81 | CDK2 (0.44) | SYKIGF1RCDK1CDK2CCNB1 | |
| SCHEMBL13897744 | 0.81 | MEN1 (0.67) | CDK1CDK2CCNB1CCNE1ABL1 | |
| SCHEMBL13897819 | 0.81 | CDK2 (0.44) | SYKIGF1RCDK1CDK2CCNB1 | |
| SCHEMBL13897842 | 0.81 | TOP2A (0.39) | SYKIGF1RCDK1CDK2CCNB1 | |
| SCHEMBL3868860 | 0.80 | EGFR (0.48) | SYKCDK1CDK2CCNB1CCNE1 | |
| SCHEMBL13897487 | 0.79 | SYK (0.44) | SYKCDK1CDK2CCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796437-B2 | Tetrahydropyran nucleic acid analogs | ISIS PHARMACEUTICALS, INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-7504410-B2 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |