Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.52 |
| ▸ | STK17A | Q9UEE5 | 5/20 | 0.52 |
| ▸ | STK17B | O94768 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 4/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.49 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | STK16 | O75716 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.46 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13898463 | 0.94 | IGF1R (0.54) | IGF1RSTK17ASTK17BCDK1KDR | |
| SCHEMBL13898422 | 0.88 | NUAK1 (0.57) | IGF1RCDK1KDRTBK1CDK2 | |
| SCHEMBL13898408 | 0.87 | STK17A (0.54) | IGF1RSTK17ASTK17BCDK1KDR | |
| SCHEMBL13898290 | 0.86 | IGF1R (0.57) | IGF1RSTK17ASTK17BCDK1KDR | |
| SCHEMBL13898376 | 0.85 | IGF1R (0.53) | IGF1RSTK17ASTK17BCDK1KDR | |
| SCHEMBL13898374 | 0.85 | IGF1R (0.58) | IGF1RSTK17ASTK17BCDK1KDR | |
| SCHEMBL13898407 | 0.85 | IGF1R (0.49) | IGF1RSTK17ASTK17BCDK1KDR | |
| SCHEMBL13898357 | 0.84 | STK17A (0.52) | IGF1RSTK17ASTK17BCDK1KDR | |
| SCHEMBL13898154 | 0.83 | MARK3 (0.53) | IGF1RSTK17ASTK17BCDK1KDR | |
| SCHEMBL13898150 | 0.82 | IGF1R (0.49) | IGF1RSTK17ASTK17BCDK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504410-B2 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504410-B2 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |