Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.50 |
| ▸ | PPARA | Q07869 | 14/20 | 0.50 |
| ▸ | PPARD | Q03181 | 11/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13899547 | 1.00 | PPARG (0.50) | PPARGPPARAPPARDS1PR1SPHK1 | |
| SCHEMBL13899475 | 0.92 | PPARG (0.50) | PPARGPPARAPPARDS1PR1FFAR1 | |
| SCHEMBL10184378 | 0.92 | PPARG (0.50) | PPARGPPARAPPARDS1PR1FFAR1 | |
| SCHEMBL10184424 | 0.92 | PPARA (0.54) | PPARGPPARAPPARDS1PR1FFAR1 | |
| SCHEMBL13899410 | 0.92 | PPARA (0.54) | PPARGPPARAPPARDS1PR1FFAR1 | |
| SCHEMBL13906073 | 0.90 | PPARG (0.53) | PPARGPPARAPPARDS1PR1SPHK1 | |
| SCHEMBL13906003 | 0.87 | PPARG (0.51) | PPARGPPARAPPARDS1PR1SPHK1 | |
| SCHEMBL10184601 | 0.85 | PPARG (0.54) | PPARGPPARAPPARDS1PR1FFAR1 | |
| SCHEMBL10184745 | 0.84 | FFAR1 (0.53) | PPARGPPARAPPARDS1PR1FFAR1 | |
| SCHEMBL10185919 | 0.84 | FFAR1 (0.53) | PPARGPPARAPPARDS1PR1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |