Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM4B | O94953 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 2/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3326011 | 0.77 | EGFR (0.45) | EGFRKDM4CKDM4AKDM4BKDM5C | |
| SCHEMBL12559902 | 0.77 | EGFR (0.45) | EGFRKDM4CKDM4AKDM4BKDM5C | |
| SCHEMBL29375518 | 0.77 | EGFR (0.45) | EGFRKDM4CKDM4AKDM4BKDM5C | |
| SCHEMBL6836406 | 0.77 | EGFR (0.45) | EGFRKDM4CKDM4AKDM4BKDM5C | |
| SCHEMBL244857 | 0.77 | PDE4A (0.55) | EGFRKDM4CKDM4AKDM4BKDM5C | |
| SCHEMBL4870134 | 0.77 | PI4KA (0.55) | EGFRKDM4CKDM4AKDM4BKDM5C | |
| SCHEMBL8252687 | 0.77 | EGFR (0.45) | EGFRKDM4CKDM4AKDM4BKDM5C | |
| SCHEMBL29650477 | 0.77 | PI4KA (0.55) | EGFRKDM4CKDM4AKDM4BKDM5C | |
| SCHEMBL6371635 | 0.72 | EGFR (0.42) | EGFRKDM4CKDM4AKDM4BKDM5C | |
| SCHEMBL22337664 | 0.72 | EGFR (0.42) | EGFRKDM4CKDM4AKDM4BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504397-B2 | mTOR inhibitor compounds | KUDOS PHARMACEUTICALS LTD. (GB) | 2009-03-17 | — | — | US | disclosed |
| US-7504397-B2 | mTOR inhibitor compounds | KUDOS PHARMACEUTICALS LTD. (GB) | 2009-03-17 | — | — | US | disclosed |