Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5962465 | 0.85 | KDM4E (0.53) | TSHRKDM4EPOLBTDP1NPSR1 | |
| SCHEMBL25822548 | 0.79 | CHRM2 (0.49) | TSHRKDM4EPOLBTDP1NPSR1 | |
| SCHEMBL24045844 | 0.77 | KDM4E (0.49) | TSHRKDM4EPOLBTDP1NPSR1 | |
| SCHEMBL12819456 | 0.77 | KDM4E (0.68) | TSHRKDM4EPOLBTDP1NPSR1 | |
| SCHEMBL30086100 | 0.77 | KDM4E (0.58) | TSHRKDM4EPOLBTDP1NPSR1 | |
| SCHEMBL31059181 | 0.77 | KDM4E (0.68) | TSHRKDM4EPOLBTDP1NPSR1 | |
| SCHEMBL31059180 | 0.77 | KDM4E (0.68) | TSHRKDM4EPOLBTDP1NPSR1 | |
| SCHEMBL229256 | 0.77 | KDM4E (0.58) | TSHRKDM4EPOLBTDP1NPSR1 | |
| SCHEMBL6033690 | 0.76 | KDM4E (0.67) | TSHRKDM4EPOLBTDP1NPSR1 | |
| Hydrochloric Acid SCHEMBL29367467 | 0.75 | KDM4E (0.57) | TSHRKDM4EPOLBTDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504391-B2 | Selective D1/D5 receptor antagonists for the treatment of obesity and CNS disorders | SCHERING CORPORATION (US) | 2009-03-17 | — | — | US | disclosed |