Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 16/20 | 0.71 |
| ▸ | DRD2 | P14416 | 11/20 | 0.71 |
| ▸ | DRD5 | P21918 | 7/20 | 0.71 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 2/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.44 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.44 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.44 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.44 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.44 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.44 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.44 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13901046 | 0.85 | DRD1 (0.71) | DRD1DRD2DRD5ADCY5DRD4 | |
| SCHEMBL13901044 | 0.79 | DRD1 (0.72) | DRD1DRD2DRD5ADCY5GFER | |
| SCHEMBL10693955 | 0.74 | DRD1 (0.70) | DRD1DRD2DRD5ADCY5GFER | |
| SCHEMBL13007204 | 0.73 | DRD1 (1.00) | DRD1DRD2DRD5ADCY5GFER | |
| SCHEMBL10747651 | 0.71 | ADCY5 (0.58) | DRD1DRD2DRD5ADCY5GFER | |
| Bromide SCHEMBL10689985 | 0.71 | DRD1 (0.70) | DRD1DRD2DRD5ADCY5GFER | |
| SCHEMBL28663486 | 0.70 | ADCY5 (0.70) | DRD1DRD2DRD5ADCY5GFER | |
| SCHEMBL13901048 | 0.70 | DRD1 (0.66) | DRD1DRD2DRD5ADCY5GFER | |
| Bromide SCHEMBL11606204 | 0.69 | ADCY5 (0.69) | DRD1DRD2DRD5ADCY5GFER | |
| SCHEMBL10745268 | 0.69 | ADCY5 (0.60) | DRD1DRD2DRD5ADCY5GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504391-B2 | Selective D1/D5 receptor antagonists for the treatment of obesity and CNS disorders | SCHERING CORPORATION (US) | 2009-03-17 | — | — | US | disclosed |
| US-7504391-B2 | Selective D1/D5 receptor antagonists for the treatment of obesity and CNS disorders | SCHERING CORPORATION (US) | 2009-03-17 | — | — | US | disclosed |