Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.61 |
| ▸ | NPC1 | O15118 | 10/20 | 0.61 |
| ▸ | RAB9A | P51151 | 10/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CASP3 | P42574 | 2/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.54 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13905630 | 0.88 | MEN1 (0.54) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL13905684 | 0.87 | MEN1 (0.53) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL4168402 | 0.85 | KMT2A (0.58) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL13905642 | 0.85 | FYN (0.52) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL4175269 | 0.84 | MEN1 (0.50) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL4179850 | 0.83 | FYN (0.71) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL4178628 | 0.83 | KMT2A (0.69) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL4178858 | 0.81 | FYN (0.57) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL4175416 | 0.81 | LCK (0.60) | MEN1KMT2ANPC1RAB9ACASP3 | |
| SCHEMBL4174275 | 0.81 | LCK (0.60) | MEN1KMT2ANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069315-A1 | Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders | SIVASANKARAN RAJEEV | 2009-03-12 | — | — | US | disclosed |
| US-20090069315-A1 | Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders | SIVASANKARAN RAJEEV | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069315-A1 | Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders | EPHA5, EPHA7, EPHA1 | MEN1 4377/4885KMT2A 3248/4885NPC1 1374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.