Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 17/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13721935 | 0.88 | GSK3B (0.53) | GSK3BNPC1ALDH1A1MAPT | |
| SCHEMBL13910333 | 0.83 | GSK3B (0.70) | GSK3B | |
| SCHEMBL4028435 | 0.82 | GSK3B (1.00) | GSK3B | |
| SCHEMBL13910329 | 0.81 | GSK3B (0.89) | GSK3B | |
| SCHEMBL13910508 | 0.81 | GSK3B (0.80) | GSK3B | |
| SCHEMBL13910844 | 0.81 | GSK3B (0.81) | GSK3B | |
| SCHEMBL13910852 | 0.81 | GSK3B (0.77) | GSK3B | |
| SCHEMBL13910358 | 0.80 | GSK3B (0.76) | GSK3B | |
| SCHEMBL13910399 | 0.80 | GSK3B (0.79) | GSK3B | |
| SCHEMBL13910321 | 0.80 | GSK3B (0.90) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427720-B1 | 3-SUBSTITUTED-4-PYRIMIDONE DERIVATIVES | MITSUBISHI TANABE PHARMA CORP (JP) | 2009-03-04 | — | — | EP | disclosed |
| US-7427615-B2 | 3-substituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2008-09-23 | — | — | US | disclosed |
| US-7427615-B2 | 3-substituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2008-09-23 | — | — | US | disclosed |