Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | PPARG | P37231 | 2/20 | 0.54 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.54 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13913547 | 0.91 | ADORA1 (0.71) | KDM4EMEN1KMT2AHTTALOX15 | |
| SCHEMBL13913630 | 0.90 | ADORA1 (0.71) | KDM4EMEN1KMT2AHTTALOX15 | |
| SCHEMBL13913789 | 0.90 | ADORA1 (0.71) | KDM4EMEN1KMT2AHTTALOX15 | |
| SCHEMBL13913689 | 0.89 | ADORA1 (0.70) | MEN1KMT2AALOX15ADORA1ALDH1A1 | |
| SCHEMBL13913701 | 0.87 | KDM4E (0.65) | KDM4EMEN1KMT2AHTTALOX15 | |
| SCHEMBL13913664 | 0.87 | ADORA1 (0.58) | MEN1KMT2AALOX15ADORA1ALDH1A1 | |
| SCHEMBL13914095 | 0.87 | ADORA1 (0.55) | KDM4EMEN1KMT2AALOX15HSD17B10 | |
| SCHEMBL13913825 | 0.85 | ADORA1 (0.52) | KDM4EMEN1KMT2AHTTALOX15 | |
| SCHEMBL13913981 | 0.84 | ADORA1 (0.56) | KDM4EHTTALOX15MAPK1HSD17B10 | |
| SCHEMBL13913698 | 0.83 | ADORA1 (0.81) | KDM4EMEN1KMT2AHTTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |