Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13913871 | 0.90 | MEN1 (0.70) | HSD17B10MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL13914104 | 0.88 | MEN1 (0.67) | HSD17B10MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL13913920 | 0.87 | MAPK1 (0.66) | HSD17B10MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL13913941 | 0.85 | MAPK1 (0.63) | HSD17B10MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL13914008 | 0.85 | ADORA1 (0.73) | ADORA1KDM4ENPSR1HTT | |
| SCHEMBL13913909 | 0.85 | HSD17B10 (0.66) | HSD17B10MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL13914017 | 0.83 | ADORA1 (0.64) | ADORA1KDM4ENPSR1HTT | |
| SCHEMBL13914011 | 0.83 | ADORA1 (0.53) | HSD17B10MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL13914009 | 0.83 | ADORA1 (0.65) | HSD17B10MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL13914019 | 0.82 | ADORA1 (0.57) | HSD17B10MAPK1ALDH1A1ALOX15HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |