Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.80 |
| ▸ | ABL1 | P00519 | 2/20 | 0.63 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.63 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.52 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13914453 | 0.96 | RET (0.74) | RETABL1ALKSIRT1NPSR1 | |
| SCHEMBL13913651 | 0.95 | RET (0.73) | RETABL1ALKSIRT1NPSR1 | |
| SCHEMBL13914428 | 0.93 | RET (0.71) | RETABL1ALKSIRT1NPSR1 | |
| SCHEMBL13914414 | 0.93 | RET (0.72) | RETABL1ALKSIRT1NPSR1 | |
| SCHEMBL13914433 | 0.92 | RET (0.69) | RETABL1ALKSIRT1NPSR1 | |
| SCHEMBL13914420 | 0.91 | RET (0.68) | RETABL1ALKSIRT1NPSR1 | |
| SCHEMBL13914434 | 0.91 | RET (0.69) | RETABL1ALKSIRT1NPSR1 | |
| SCHEMBL13914431 | 0.91 | RET (0.69) | RETABL1ALKSIRT1NPSR1 | |
| SCHEMBL13914424 | 0.91 | RET (0.68) | RETABL1ALKSIRT1NPSR1 | |
| SCHEMBL13914741 | 0.90 | RET (0.75) | RETABL1ALKSIRT1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |