Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 14/20 | 0.56 |
| ▸ | LDHA | P00338 | 2/20 | 0.56 |
| ▸ | LDHB | P07195 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14017957 | 0.94 | AKR1B1 (0.56) | AKR1B1LDHALDHBPOLBALB | |
| SCHEMBL2622250 | 0.91 | AKR1B1 (0.66) | AKR1B1LDHALDHBPOLBALB | |
| SCHEMBL13446155 | 0.87 | AKR1B1 (0.62) | AKR1B1LDHALDHBPOLBALB | |
| SCHEMBL2622251 | 0.68 | AKR1B1 (0.71) | AKR1B1LDHALDHBPOLBALB | |
| SCHEMBL2622273 | 0.66 | AKR1B1 (0.48) | AKR1B1LDHALDHBPOLBALB | |
| Gossypol Acetic Acid SCHEMBL31607468 | 0.66 | AKR1B1 (0.64) | AKR1B1LDHALDHBPOLBALB | |
| Gossypol Acetic Acid SCHEMBL29699445 | 0.66 | AKR1B1 (0.64) | AKR1B1LDHALDHBPOLBALB | |
| SCHEMBL2622260 | 0.62 | AKR1B1 (1.00) | AKR1B1LDHALDHBPOLBALB | |
| SCHEMBL12554423 | 0.60 | POLB (0.77) | POLBALDH1A1GAAHPGDKDM4E | |
| SCHEMBL22700785 | 0.60 | ALB (0.68) | AKR1B1LDHALDHBPOLBALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082424-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | REGENTS OF THE UNIVERSITY OF MICHIGAN, THE | 2009-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082424-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | BCL2, BCL2L1, BCL2L2 | AKR1B1 1880/4885LDHA 3274/4885LDHB 3231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.