Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.67 |
| ▸ | PDE11A | Q9HCR9 | 14/20 | 0.67 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13918945 | 1.00 | PDE4B (0.67) | PDE4BPDE11APDE10A | |
| SCHEMBL8275173 | 0.93 | PDE4B (0.67) | PDE4BPDE11APDE10A | |
| SCHEMBL13919870 | 0.90 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13919878 | 0.90 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13919504 | 0.90 | PDE4B (0.61) | PDE4BPDE11APDE10A | |
| SCHEMBL13919258 | 0.89 | PDE4B (0.61) | PDE4BPDE11APDE10A | |
| SCHEMBL13918942 | 0.89 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL8272916 | 0.89 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13919503 | 0.89 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13919500 | 0.89 | PDE4B (0.62) | PDE4BPDE11APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |